|
KMID : 0368820220610040274
|
|
Journal of the Korean Neuropsychiatr Association
2022 Volume.61 No. 4 p.274 ~ p.280
|
|
|
Korean Medication Algorithm Project for Bipolar Disorder 2022: Treatment Strategy According to Safety and Tolerability
|
|
Park Sung-Yong
Bahk Won-Myong
Woo Young-Sup
Jeong Jong-Hyun
Yoon Bo-Hyun
Seo Jeong-Seok
Choo Il-Han
Yang Chan-Mo
Kim Won
Lee Jung-Goo
Shim Se-Hoon
Jung Myung-Hun
Jon Duk-In
Kim Moon-Doo
Sohn In-Ki
|
|
|
Abstract
|
|
|
Objectives The safety and tolerability of drugs are very important to ensure compliance and efficacy in the treatment of bipolar disorders. An expert opinion survey was conducted on treatment strategies in various special clinical situations, such as patients with significant weight gain, reporting characteristic drug side effects, low drug adherence, pregnant and reproductive women, and genetic counseling.
Methods A written survey that addressed treatment strategies related to safety and tolerability was prepared. The survey focused on significant weight gain, characteristic drug side effects, low drug adherence, treatment of pregnant and reproductive women, and genetic counseling. Eighty-seven experts in the review committee completed the survey
Results In the case of weight gain occurring during drug treatment, it was considered preferable to replace the treatment drug with a drug that caused less weight gain, such as lamotrigine, aripiprazole, or ziprasidone. If there was a significant weight gain due to the treatment drug, it was considered preferable to intervene as soon as possible. In the case of hyperprolactinemia, it was considered preferable to change the drug. It was recommended that the drug beto discontinued in case of a benign rash as seen in patients treated with lamotrigine. For improving drug adherence, there was an increased preference for long-acting injections. It was also opined that antipsychotics should be used with great caution in pregnant or reproductive women.
Conclusion Treatment strategies in various clinical situations related to the safety and tolerability of drugs for bipolar disorder have been described. It is hoped that this information would be useful in practical clinical situations.
|
|
|
KEYWORD
|
|
|
Bipolar disorder, Tolerability, Drug adherence, Reproductive women
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|